Current research of microRNAs in ocular neovascularization
10.3760/cma.j.issn.2095-0160.2012.04.023
- VernacularTitle:miRNA在新生血管性眼病中作用的研究进展
- Author:
Qi, ZHOU
;
Jun, ZHANG
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Ocular neovascularization;
Therapeutic approach
- From:
Chinese Journal of Experimental Ophthalmology
2012;30(4):380-384
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs(miRNAs) are a type of highly conserved,small non-coding RNAs,which powerfully regulate gene expression at the posttranscriptional level.In humans,it modulates about 30％ of protein coding genes.Ocular neovascularization is one of the most important clinical problems in ophthalmology and a common cause of blindness.Recent studieshavedemonstrated that miRNAs play a crucial rolein the development of ocular neovascularization.The use of miRNAs provides novel therapeutic approaches for ocular neovascularization.Here,we describe our understanding of the functions and expressions of miRNAs in eyes,the relationship among miRNAs,ocular neovascularization and angiogenic factors,and the current research of miRNAs in diabetic retinopathy.
