Kringle domain and its inhibition of ocular neovascularization
10.3760/cma.j.issn.2095-0160.2011.06.019
- VernacularTitle:Kringle结构及其在眼部新生血管性疾病中的应用
- Author:
Li, SU
- Publication Type:Journal Article
- Keywords:
Ocular neovascular disease;
Pathologic;
Angiogenesis inhibitors;
Kringles domains
- From:
Chinese Journal of Experimental Ophthalmology
2011;29(6):565-569
- CountryChina
- Language:Chinese
-
Abstract:
Ocular neovascularization,abnormal formation of new vessels from pre-existing capillaries,is a special pathologic change of many ocular diseases,including diabetic retinopathy and retinopathy of prematurity,etc..Ocular neovascular diseases comprise the common causes of blindness in millions of people.Recent studies showed that kringle domains from many endogenous proteins inhibit the proliferation and migration of endothelial cells in vitro and neovascular formation in vivo.Hence kringle domain with conservative structure has been considered as a potential inhibitor of neovascularization.The update studies on antiangiogenic kringle domains and its inhibition on ocular neovascularization were summarized.
