Role of β-glucan receptor dectin-1 in anti-fungal infection of cornea
10.3760/cma.j.issn.2095-0160.2012.03.021
- VernacularTitle:Dectin-1在角膜抗真菌免疫中的作用
- Author:
Ying-feng, HU
- Publication Type:Journal Article
- Keywords:
Dectin-1;
β-Glucan;
Fungus;
Immune response
- From:
Chinese Journal of Experimental Ophthalmology
2012;30(3):270-272
- CountryChina
- Language:Chinese
-
Abstract:
β-Glucan is a kind of highly conservative composition on fungal cell wall.As a recognition receptor of β-glucan,dendriticcell-associatedC-typelectin-1 (dectin-1)widely distributeinsingle-nuclea macrophages system,dendritic cells ( DC )and neutrophil cells.Through the identification of fungal cell wall composition and cells signal transduction,dectin-1 induces the production of cytokine and chemokine and then starts a nonspecific and specific immunity response.Dectin-1 plays a key role in antifungal immune response.Here,the molecular structure,tissue cells,signal transmission and the immune inflammation role of dectin-1 in corneal infection were reviewed.
