Biological targeted therapy of after-cataract
10.3760/cma.j.issn.2095-0160.2012.01.023
- VernacularTitle:后发性白内障的生物靶向治疗
- Author:
Rui-ling, ZHAO
- Publication Type:Journal Article
- Keywords:
Posterior capsular opacification;
Lens epithelial cells;
Biological therapy;
Immunotherapy;
Gene therapy
- From:
Chinese Journal of Experimental Ophthalmology
2012;30(1):91-93
- CountryChina
- Language:Chinese
-
Abstract:
After cataract,called posterior capsule opacification (PCO),is resulted from residual cortex or the proliferation of lens epithelial cells following extracapsular cataract extraction,and it is thought to be themost common complication and the main reason of eyesight decline after modern extracapsular cataract surgery.Lens epithelial cells remaining in the capsular bag after surgery play an important role in PCO.How to prevent and treat PCO is the focus of attention of eye scholars,and the major treating methods are administration of drug,laser and surgery.Recent years,scholars in home and abroad are interested in biological targeted therapy to prevent PCO,such as the topical application of antiproliferation of LECs,preparation of vector transfected immunotoxin and gene theropy etc.The research progress in recent years in the biological therapy of PCO were reviewed.
