Research advance in application of tissue engineering in degenerative retinal diseases
10.3760/cma.j.issn.2095-0160.2011.07.022
- VernacularTitle:组织工程在视网膜退行性疾病中的应用进展
- Author:
Jing-xue, ZHANG
- Publication Type:Journal Article
- Keywords:
Stem cells;
Degenerative retinal diseases;
Tissue engineering;
Transplantation
- From:
Chinese Journal of Experimental Ophthalmology
2011;29(7):665-668
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenic basis of degenerative retinal diseases is structural and functional abnormality of neuron of retina.The irreversible damage of visual function is the unfortunate results of degenerative retinal diseases,and some effective treating approach to these blindness eye diseases is still in expectation.In recent years,stem cells replacement therapy is increasingly developed and is a prospective way for degenerative retinal diseases.But some formidable challenges for successfully grafting cells to the retina are waiting for further solving,such as migration,survival,and differentiation of the stem cells etc.Recent studies showed that retinal tissue engineering technique may be a good alternation to address all the problems mentioned above.The current advances in stem cell and tissue engineering retina researches,including selectable seed cells,appropriate scaffold materials and transferring method in vivo,are reviewed in this paper.
