Research progress in correlation factor on fibrosis of proliferative diabetic retinopathy
10.3760/cma.j.issn.2095-0160.2011.05.020
- VernacularTitle:增生型糖尿病视网膜病变纤维化相关因子的研究进展
- Author:
Hui-feng, RONG
- Publication Type:Journal Article
- Keywords:
Proliferative diabetic retinopathy;
Fibrosis;
Cytokine;
Extracellular matrix;
Marx metalloproteinases
- From:
Chinese Journal of Experimental Ophthalmology
2011;29(5):473-476
- CountryChina
- Language:Chinese
-
Abstract:
The fibrovascular membrane of proliferative diabetic retinopathy(PDR)cause severe damage to the structure and function of eye.The pathogenesis and development of fibrovascular membrane are associated with muhipie cellular factors,such as transforming growth factor(TGF),connective tissue growth factor(CTGF),basic fibroblast growth factor(bFGF),vascular endothelial growth factor(VEGF),platelet-derived growth factor(PDGF),tumor necrosis factor(TNF),extracellular matrix(ECM),matrix metalloproteinases(MMPs),endothelin and chemotactic factor,etc..So,the molecular mechanism of fibrovascular membrane of PDR is extremely complex.The relationship of pathogenesis on the fibrosis of PDR to cytokines,extracellular matrix,MMPs and other factors were summarized.
