Current researches and existing problems of molecular biology in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

VernacularTitle:新生血管性年龄相关性黄斑变性和息肉状脉络膜血管病变的分子生物学研究现状及存在问题
Author: Feng, WEN ; Kun-fang, WU
Publication Type:Journal Article
Keywords: Age-related macular degeneration; Polypoidal choroidal vasculopathy; Gene; Molecular biology
From: Chinese Journal of Experimental Ophthalmology 2011;29(4):289-292
CountryChina
Language:Chinese
Abstract: Neovascular age-related macular degeneration(nAMD)and polypoidal choroidal vasculopathy (PCV)are leading causes of blindness and visual impairment in older population.They are both with a hemorrhagic and exudative macular disorder.PCV has been proposed to be a sub-type of nAMD,hut this is a matter of controversy.Although several genes are found to be associated with PCV and nAMD(CFH,ARMS2/HTRA1),but more genes show no common association with the two diseases.such as BF/C2,Elastin,PEDF,SERPlNG1,VEGF,APOE genes.All these Results might imply that PCV and nAMD have different pathogenesis.But in the current state of our knowledge for PCV and nAMD.we still could not conclude if they are the same diseases.The purpose of these review is to discuss the recent progress in the molecular biology of PCV and nAMD.