An experimental study on protective effects of flunarizine in retinal ischemic injury
- VernacularTitle:氟桂嗪对视网膜缺血损伤保护作用的实验研究
- Author:
Tong, LI
;
Jianzong, LIU
- Publication Type:Journal Article
- Keywords:
retina;
ischemic;
injury;
flunarizine;
MDA
- From:
Chinese Journal of Experimental Ophthalmology
2001;19(1):23-25
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the protective effects of flunarizine（FZN） in retinal ischemic injury．MethodsFor the experimental group and the treated group in ischemic reperfusion different stages, the contents of lipid peroxide metabolim malondialdehyde （MDA） in rabbites’ retinal tissues were detected by using TBA．ResultsThe contents of MDA in the experimental and treated groups at 30 min，60 min and 90 min of reperfusion increased remarkably compared with that of the normal control group（P＜0.01)．The contents of MDA in the treated group at 30 min，60 min and 90 min of reperfusion were much lower than that of MDA in the experimental group at 30 min，60 min and 90 min of reperfusion respectively（P＜0.01）．ConclusionIntracellular calcium overload may be involved in pathophysiologic process of retinal ischemic injury．Flunarizine has the protective effects in retinal ischemic injury.
