Research progress of Roundabout 4 in tumor angiogenesis and endothelial cell migration
10.3760/cma.j.issn.2095-0160.2011.02.022
- VernacularTitle:Roundabout 4在肿瘤血管新生及细胞迁移中作用的研究进展
- Author:
Yan, CHENG
- Publication Type:Journal Article
- Keywords:
Roundabout 4;
Endothelium;
Cell migration;
Angiogenesis;
Retinal ganglion cell
- From:
Chinese Journal of Experimental Ophthalmology
2011;29(2):188-191
- CountryChina
- Language:Chinese
-
Abstract:
Retinal neovascularization ( RNV) is a serious and causing-blindness eye disease in human beings. It occurs in severe eye diseases including diabetic retinopathy age-related tnacular degeneration etc.. In recent years vascular growth factor is the most important factors in controlling retinal endothelium proliferation and retinal neovacularization. Roundabout 4 ( Robo4 also known as Magic Roundabout) is a transmembrane receptor protein. Expression of Robo4 is restricted exclusively to sites of active angiogenesis. It has been recognized that Robo4 can control endothelial cell migration and the sprouting of new blood vessels neutralize signaling through the vascular growth factor and maintain vessel integrity. These findings could lead to new therapeutic target for RNV. The roles of Robo4 in angiogenesis and endothelial cell migration were discussed and basic research in the eye was reviewed.
