Current progress in pathogenesis and prevention of hyperoxia-induced ocular injury
10.3760/cma.j.issn.2095-0160.2011.02.021
- VernacularTitle:高氧诱导眼损伤机制及其防治的研究进展
- Author:
Qi, LI
- Publication Type:Journal Article
- Keywords:
Hyperoxia;
Oxidative stress;
Lipid peroxidation;
Lens;
Retina
- From:
Chinese Journal of Experimental Ophthalmology
2011;29(2):184-187
- CountryChina
- Language:Chinese
-
Abstract:
Hyperoxia, including hyperbaric oxygen (HBO) and high-concentration oxygen (HO), has an important therapeutic effect on various ophthalmological diseases, such as retinal vein occlusion, ischemic optic neuropathy and central serous chorioretinopathy. However, excessive inhalation of oxygen of high-concentration or high atmospheric pressure can cause damage of ocular tissue, in which the lens opacity and retinopathy of prematurity (ROP) are the most common complications following hyperoxia exposure. At present, the pathogenesis of hyperoxia-induced ocular injury is still unclear thoroughly, and it may be related to oxidative stress, lipid peroxidation and inflammation. This article reviewed the current advance in the mechanism and the potential prevention of hyperoxia-induced the lens,retina and other ocular injuries.
