The Relationship Between the Expression ofMetalloproteinase- 2 and Laryngeal Squamous Cell Carcinoma
- VernacularTitle:基质金属蛋白酶-2与喉癌的相关性研究
- Author:
Kuanlin, XIAO
;
Gangxun, HE
;
Xueming, CHEN
- Publication Type:Journal Article
- Keywords:
laryngeal squamous cell carcinomametalloproteinasebasement menbrane
- From:Journal of Shanghai Jiaotong University(Medical Science)
2000;20(5):418-420
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the expression of matrix metallopro-teinase- 2(MMP- 2) and the clinical pathological characteristics of laryngeal squamous cell carcinoma.Methods Irnmunohistochemistry technique (ABC) was used to detect the expression and location ofMMP- 2 in the tissue of 43 cases with laryngeal squamous cell carcinoma. ResultsThe positive ex-pression rate of the MMP - 2 protein was 29(67.4% ) among the 43 laryngeal tumor tissues. It was sig-nificantly related to metastasis of the cervical lymph nodes (P<0.05). MMP- 2 was immunolocalizedon the membranes and intracytoplasm of metastatic cluster tumor cells or the tumor cells adjacent to thebasement membrane. ConclusionThese results suggest that MMP- 2 plays an important role in thetumor invasion and metastasis of laryngeal squamous cell carcinoma.
