Clinical Significance of Serum Type Ⅳ Collagen Assay for the Diagnosis of Hepatic Fibrosis
- VernacularTitle:血清Ⅳ型胶原诊断肝纤维化的价值
- Author:
Yongqiang, LI
;
Yimei, CAI
- Publication Type:Journal Article
- Keywords:
hepatic fibrosisserum Ⅳ collagen
- From:Journal of Shanghai Jiaotong University(Medical Science)
2000;20(5):455-457
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the clinical significance of serum type Ⅳ collagen( Ⅳ - C) levelsfor the diagnosis of hepatic fibrosis. MethodsSerum levels of Ⅳ - C were measured in 209 patientswith viral hepatitis and 53 healthy persons by ELISA. ResultsCompared with the normal group,the serum Ⅳ - C level was significantly increased in patients with chronic moderate hepatitis and wasthe highest in patients with chronic severe hepatitis and hepatic cirrhosis( P < 0.01 ). There was no sig-nificant difference in the serum Ⅳ- C level among acute viral hepatitis, chronic mild hepatitis and con-trols ( P >0.05). There was significant difference in the serum Ⅳ - C level in patients with hepaticcirrhosis by Child- Pugh grading( P < 0.01 ). The serum Ⅳ - C level was positively correlated withthe degree of hepatic fibrosis and the severity of hepatic diseases. ConclusionThe meastrement of serumⅣ- C may be useful for assessment of the degree of hepatic fibrosis and progrosis of chronic hepatitis.
