Significance of Detection of Serum HBV DNA in Hepatitis B Patients
- VernacularTitle:乙型肝炎患者血清中HBV DNA的临床意义
- Author:
Dongmei, SHI
- Publication Type:Journal Article
- Keywords:
branch DNA signal amplificaiton assayquantitative of HBV DNAhepatitis Bliver cirrhosishepatocellular carcinoma
- From:Journal of Shanghai Jiaotong University(Medical Science)
2000;20(6):527-528
- CountryChina
- Language:Chinese
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Abstract:
Objective To study the relationship between the serum HBV DNA level and theprogress of hepatitis B. MethodsHBV DNA was quantified by branch DNA signal amplification as-say(bDNA). 172 patients of different clinical types infected with HBV were investigated for HBVDNA. Results At the less than 0.7mmol/ml of HBV DNA level, 88.0% were acute patients,32.2% chronic,66.7% chronic with the fulminant hepatic failure, 19.4% cirrhotic, and 37.5% HCCpatients. The degree of fibrosis in the liver tissue is significantly higher in the group with more than 35years old. than in that with less than 35 years old ( P < 0.01 ). All chronic patients were analyzed,HBV DNA level is significantly higher in patients less than 35 years old than in patients more than 35years old ( P < 0.01 ). Conclusion This research demonstrated that existence and replication ofHBV were the main causes for the progress of hepatitis B.
