Expression and Significance of Ets－ 1 in Chondrosarcoma and Osteochondroma of the Jaws
- VernacularTitle:Ets－1在颌骨软骨肉瘤和骨软骨瘤中的表达及意义
- Author:
Xiaohui, SI
;
Zheng, LIU
- Publication Type:Journal Article
- Keywords:
Ets－ 1chondrosarcomaosteochondromairnmunohistochemistryEts(E26
- From:Journal of Shanghai Jiaotong University(Medical Science)
2000;20(6):550-552
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the expression and significance of Ets－ 1 (E26 transformation－specific) in chondrosareoma and osteochondroma of the jaws.MethodsEts－ 1 expression was de-tected by immunohistochemistry in 20 cases of chondrosarcoma and 8 cases of osteochondroma of thejaws.Results12 of the 20 cases of chondrosarcoma (t50%) showed an Ets－ 1 positive reastion. Thepositive rates of grade Ⅱ and grade Ⅲ were significantly higher than that of grade Ⅰ ( P < 0.05 ). Re-current cases showed a higher Ets － 1 positive rate than primary ones ( P < 0.05 ). Ets － 1 was presentin 12.5 % (1/8) osteochondroma. The positive rate was significantly different between chondrosarcomaand osteochondrorna ( P < 0.05 ).ConclusionThe results indicate that Ets－ 1 is overexpressed inchondrosarcoma of the jaws and correlated with its pathological grade and recurrence.
