Complete Genomic Sequence Analysis of a New SV40 Isolate
- Author:
Xue-mei, ZHANG
;
Yan-chun, CHE
;
Jing-jing, WANG
;
Long-ding, LIU
;
Ming-xue, XIE
;
Qi-han, LI
- Publication Type:Journal Article
- Keywords:
SV40;
T-Ag;
Regulatory region
- From:Virologica Sinica
2007;22(1):41-45
- CountryChina
- Language:Chinese
-
Abstract:
The genome of a new SV40 strain(SV-IMB)isolated from a rhesus monkey was completely sequenced and compared with other isolates.The results showed that the whole genome contains 5246bp,and the average identity of SV-IMB was 98.1% as compared to other SV40 isolates.Its regulatory region is composed of a complete enhancer and a defective enhancer.Amino acid changes occurred to some extent in both the large T antigen (T-Ag) and VP1 region.The findings demonstrate that the SV-IMB is a new SV40 isolate.
