Effect of over Expression of P53 and C-erbB-2 on Prognosis of Breast Cancer
- VernacularTitle:P53和C-erbB-2过表达与乳腺癌预后的关系
- Author:
Yong-shun, PU
;
Jin-liang, ZHOU
;
Fang, WANG
- Publication Type:Journal Article
- From:Journal of Shanghai Jiaotong University(Medical Science)
2001;21(2):170-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study is to assess the prognostic significance of over expression of P53, C-erbB-2 in breast cancer. Methods In 48 patients with breast cancer the expression of P53, C-erbB-2, PCNA and ER was determined by the S-P staining immunohistochemical technique. Results The positive rate of P53, C-erbB-2, PCNA and ER were 54％, 43.7％ 52％, 41.6％ seperateiy. Expression of P53 and C-erbB-2 increased with the class of the tissuess. There is significant difference between grade Ⅰ and Ⅱ , Ⅲ (P＜0.05) as well as between lymph node metastasis (＋) and lymph node metastasis (-) patients (P＜0.05). Conclusion The over expression of P53, C-erbB-2 may be a useful prognostic indicator in breast cancer.
