Costimulatory molecule B7-H1 on the immune escape of bladder cancer and its clinical significance.
- Author:
Yonghua, WANG
;
Qianyuan, ZHUANG
;
Siwei, ZHOU
;
Zhiquan, HU
;
Ruzhu, LAN
- Publication Type:Journal Article
- MeSH:
Antigens, CD/genetics;
Antigens, CD/*metabolism;
Antigens, CD80/genetics;
Antigens, CD80/*metabolism;
Prognosis;
Tumor Escape/*genetics;
Urinary Bladder Neoplasms/*immunology;
Urinary Bladder Neoplasms/metabolism
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2009;29(1):77-9
- CountryChina
- Language:English
-
Abstract:
B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in tumor immune escape by inducing T-cell apoptosis. In order to investigate the relationship between B7-H1 and immune escape of bladder cancer, B7-H1 expression in 50 cases of bladder cancer was detected by using immunohistochemical method. Survival curves were constructed using the Kaplan-Meier method and independent prognostic factors were evaluated using the Cox regression model. Our results showed that the positive rate of B7-H1 immunostaining in normal bladder tissue and bladder cancer was 0 and 72% respectively. The expression of B7-H1 was strongly associated with the pathological grade, clinical stage and recurrence (P<0.05). The survival rate was significantly lower in patients with B7-H1 positive group than in those with B7-H1 negative group and multi-variable analysis revealed that B7-H1 could be regarded as an independent factor in evaluating the prognosis of bladder cancer. It is concluded that the expression of B7-H1 is strongly associated with neoplastic progression and prognosis of bladder cancer. The manipulation of B7-H1 may become a beneficial target for immunotherapy in human bladder cancer.
