Effects of mifepristone on fibronectin in human villus and deciduas
- VernacularTitle:米非司酮对人绒毛和蜕膜内纤维粘连蛋白表达的影响
- Author:
Ling, GAO
;
Yan, LIU
;
Duan-duan, LA
- Publication Type:Journal Article
- Keywords:
mifepristone;
medical abortion;
villus;
deciduas;
fibronectin
- From:Journal of Shanghai Jiaotong University(Medical Science)
2009;29(6):722-724
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of mifepristone on the expression of fibronectin (FN) in human villus and deciduas after termination of pregnancy. Methods Women with choice of termination of pregnancy(< 49 d) were divided into medical abortion complete group (n=15), medical abortion incomplete group(n=15) and control group (with dilatation and curettage, n=15). The villus and deciduas were collected at the third day of medical abortion or at the day of dilatation and curettage. Immunohistochemical technique was used to examine the expression of FN in villus and deciduas of these three groups. Results The positive expression rates of FN in villus and deciduas of control group were significantly higher than those of two medical abortion groups(P < 0.017), and the positive expression rates of FN of medical abortion incomplete group were significantly higher than those of medical abortion complete group (P < 0. 017). Conclusion Mifepristone can decrease the expression of FN in human villus and deciduas and interfere the condition of embryonic growth, exerting the anti-gestational effect at extracellular matrix level.
