Effects of astragaloside Ⅳ on electrocardiogram and action potential of ventricular myocytes in guinea pigs
- VernacularTitle:黄芪甙Ⅳ对豚鼠心电图及心室肌动作电位的影响
- Author:
Yun, ZHOU
;
Jun-jie, WANG
;
Wei, ZHAO
;
Chuan, ZHANG
;
Wei-dong, ZHANG
- Publication Type:Journal Article
- Keywords:
astraguloside Ⅳ;
electrocardiogram;
heart rate;
action potential;
calcium channel
- From:Journal of Shanghai Jiaotong University(Medical Science)
2009;29(6):677-680
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of astragaloside Ⅳ on electrocardiogram (ECG) and action potential of ventricular myocytes in guinea pigs. Methods ECG was recorded in vivo and ex vivo by using conventional ECG recording method from anesthetic guinea pigs and Langendoff perfusion model of hearts. Action potentials were recorded from isolated papillary muscles of right ventricles of guinea pigs by using microelectrode techniques. Results RR interval was prolonged by Astragaloside Ⅳ in a dose-dependent manner both in vivo and ex vivo. Astragaloside Ⅳ shortened action potential duration (APD), while had no effects on resting potential, action potential amplitude and maximal rate of depolarization. Conclusion Astragaloside Ⅳ exerts a negative chronotropic effect on heart and shortens APD of cardiac myocytes, which may be involved with calcium channels.
