Changes of CD4(+) CD25 (+) regulatory T cells in peripheral blood in patients with hepatocellular carcinoma before and after TACE.
- Author:
Bin, XIONG
;
Gansheng, FENG
;
Shihua, LUO
;
Huimin, LIANG
;
Lingyun, QIU
;
Chuansheng, ZHENG
;
Xi, LIU
;
Guofeng, ZHOU
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents/administration & dosage;
Carcinoma, Hepatocellular/*immunology;
Carcinoma, Hepatocellular/therapy;
Chemoembolization, Therapeutic/*methods;
Liver Neoplasms/*immunology;
Liver Neoplasms/*therapy;
T-Lymphocytes, Regulatory/*immunology
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(6):645-8
- CountryChina
- Language:English
-
Abstract:
This study investigated the changes of CD4(+) CD25(+) regulatory T cells (Tregs) in peripheral blood of patients with hepatocellular carcinoma before and after transcatheter arterial chemoembolization (TACE). The proportion of CD4(+) CD25(+) Tregs among CD4(+) T lymphocytes in peripheral blood of 33 patients with hepatocellular carcinoma was determined by flow cytometry before, 1 week and 1 month after TACE. And 25 healthy volunteers served as control. One month after TACE, the patients were divided into two groups: 22 in group A, who were in stable condition or getting better; and 10 in group B, who were deteriorating. One patient died and was excluded. The results showed that the percentage of CD4(+)CD25(+) Tregs among CD4(+) T lymphocytes did not significantly change in the 33 patients 1 week after TACE as compared with that before TACE, however, the difference was significant (P<0.01) between the patients with hepatocellular carcinoma and the healthy subjects. The percentage of CD4(+) CD25(+) Tregs among CD4(+) T lymphocytes in group A 1 month after TACE was decreased significantly in comparison with that before and 1 week after TACE (P<0.01), whereas, that in group B was increased significantly 1 month after TACE (P<0.01). It was concluded that patients with hepatocellular carcinoma had a higher proportion of CD4(+)CD25(+) Tregs in peripheral blood. TACE did not significantly affect the level of CD4(+) CD25(+) Tregs within short time (such as 1 week). The proportion of CD4(+)CD25(+) Tregs in peripheral blood 1 month after TACE was related to the prognosis of hepatocellular carcinoma.
