Relationship of HLA-A, -Cw Polymorphisms with HIV/AIDS in Chinese Yi Ethnic Group of Sichuan Province
- Author:
Kun-xue, HONG
;
Xiao-zhi, LU
;
Guang-ming, QIN
;
Jian-ping, CHEN
;
Yu-hua, RUAN
;
Hui, XING
;
Jia-hong, ZHU
;
Yi-ming, SHAO
- Publication Type:Journal Article
- Keywords:
Chinese Yi Ethnic Group;
HLA-A;
HLA-Cw;
HIV/AIDS;
Association
- From:Virologica Sinica
2007;22(4):301-306
- CountryChina
- Language:Chinese
-
Abstract:
The relationship of HLA-A, -Cw alleles on HIV infection and AIDS disease progression in the Chinese Yi ethnic group of Sichuan province were investigated. The genetic polymorphisms of HLA-A, -Cw alleles of 102 unrelated healthy Chinese Yi ethnic individuals, 68 HIV-1 infected and 21 HIV positive long-time survivors were typed by PCR-SSP assay. Statistic signifiance was determined by the χ2 test with the SPSS software. No significant differences were observed between the HLA-A, -Cw alleles of the 68 HIV-1 infected and 102 non-infected Chinese Yi control individuals. Whereas the prevalence of A*3601,Cw*14(01-03)and Cw*0304 was significantly higher in 21 long time survivors compared with 102 healthy controls with P values of 0.016, 0.016 and 0.000 by χ2 or the Fisher exact test respectively. The result implies that A*3601,Cw*14(01-03) and Cw*0304 may be associated with slow AIDS disease progression in the Chinese Yi ethnic group, further studies on this association may yield insight on the pathogenesis of HIV-1 infection.
