Interleukin-10 Promoter Polymorphism is Associated with the Predisposition to the Development of IgA Nephropathy and Focal Segmental Glomerulosclerosis in Korea.
10.3346/jkms.2005.20.6.989
- Author:
Ho Jun CHIN
1
;
Ki Young NA
;
Soo Jin KIM
;
Kook Hwan OH
;
Yon Su KIM
;
Chun Soo LIM
;
Suhnggwon KIM
;
Dong Wan CHAE
Author Information
1. Department of Internal Medicine, Hallym University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Glomerulonephritis, IGA;
Glomerulosclerosis, Focal;
Polymorphism, Single Nucleotide
- MeSH:
Alleles;
Base Sequence;
Case-Control Studies;
DNA/genetics;
Gene Frequency;
Glomerulonephritis, IGA/*genetics/*immunology;
Glomerulosclerosis, Focal/*genetics/*immunology;
Haplotypes;
Humans;
Interleukin-10/*genetics;
Korea;
Polymerase Chain Reaction;
*Polymorphism, Genetic;
Polymorphism, Restriction Fragment Length;
*Promoter Regions (Genetics);
Research Support, Non-U.S. Gov't
- From:Journal of Korean Medical Science
2005;20(6):989-993
- CountryRepublic of Korea
- Language:English
-
Abstract:
The roles of interleukin-10 (IL-10) have been emphasized in several models of glomerulonephritis (GN). Three biallelic polymorphisms within the IL-10 promoter region, at positions -1,082, -819, and -592 from the transcription initiation site, were shown to affect the level of IL-10 production. To investigate the effect of IL-10 promoter polymorphisms on the predisposition to development of GN in Korea, IL-10 promoter polymorphisms were assayed by polymerase chain reaction followed by restriction fragment length polymorphism in 108 patients with IgA nephropathy (IgAN), 49 focal segmental glomerulosclerosis (FSGS), and 100 healthy controls. In comparison with the control, the frequency of -1,082*G alleles were lower in IgAN and the frequencies of -592*C and -819*C were lower in FSGS, respectively. As for the haplotype, GCC haplotype was less frequent among IgAN than the control and ATA haplotype was more frequent among FSGS than the control (p<0.05). The frequency of intermediate producer genotypes (GCC/ACC and GCC/ATA) were lower among IgAN or FSGS than the control. Our findings suggested that IL-10 promoter polymorphism predisposed to the development of IgAN and FSGS in Korean patients.
