Selective expression of progesterone receptor in malignant melanoma was inversely correlated with PCNA.
- Author:
Jiawen, LI
;
Xianfeng, FANG
;
Xu'e, CHEN
;
Jing, CHEN
- Publication Type:Journal Article
- MeSH:
Gene Expression Regulation, Neoplastic;
Immunohistochemistry;
Melanoma/*metabolism;
Models, Biological;
Prognosis;
Proliferating Cell Nuclear Antigen/*metabolism;
Receptors, Progesterone/*biosynthesis;
Receptors, Progesterone/genetics;
Skin/metabolism;
Skin Neoplasms/metabolism
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(2):216-8
- CountryChina
- Language:English
-
Abstract:
To investigate the role of progesterone receptor (PR) expression in malignant melanoma (MM), PR and proliferative cell nuclear antigen (PCNA) expression were immunohistochemistrically evaluated in a series of 35 specimens of MM, and the correlation between the immunohistochemistrical findings and clinicopathological data was also analyzed. PR expression was detected in 25.7% (9/35) of the patients with MM. No PR expression was observed in nevi. PR expression was inversely correlated with PCNA expression (r=-0.353, P=0.026). PR expression was slightly increased in females, subjects aged under 55 y, those with ulceration, non-acral subtype and diagnosis delay longer than 1 y, but the difference was not statistically significant. Selective expression of progesterone receptor in malignant melanoma might be correlated with inhibited tumor growth.
