Experimental Inhibitory, and Pharmacokinetic Stydy on The Development of Proliferative Vitreoretinopathy by Sustained Delivery of Intravitreal Fluoropyrimidenes.
- Author:
Shin Dong KIM
1
;
Hyun Joo KIM
;
Ho Sung YANG
;
Dal Jun JUNG
;
Kwang Hyuk KIM
;
Koo Il KANG
;
Noong Joo LEE
;
Hae Kon KIM
Author Information
1. Department of Ophthalmology, School of Medicine, Kosin University, Korea.
- Publication Type:Original Article
- Keywords:
5-fluorouracil;
5-fluorouridine-5'-monophosphate;
Proliferative Vitreoretinopathy;
Liposome;
Polymer
- MeSH:
Chromatography, High Pressure Liquid;
Fibroblasts;
Fluorouracil;
Liposomes;
Polymers;
Retina;
Vitreoretinopathy, Proliferative*
- From:Journal of the Korean Ophthalmological Society
1995;36(3):427-441
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The efficacy of the sustained release-delivery system was tested in suppressing the development of proliferative vitreoretinopathy(PVR) with intravitreal Fluoropyrimidines(5-Fu: FU, Fluorouridine: FUD, 5-Fluoro-5'-monophosphate: FUMP). PVR was induced in one-hundred-eightyeight eyes of one-hundred-twenty rahbits by intravireal injection of homologous dermal fibroblasts(250.000 cells/0.1 ml). Each drugs were encapsulated with liposome(LFU. LFUD. LFUMP) or polymer(PFU. PFUD) and non-coated drugs wer e used as controls. 3 weeks after injections of fibroblasts, retina detached in 50.0% of control eyes. Among treated eyes, the detachment rates in percentage are as follows; FU 37.5, FUD 50.3, LFU 37.5, LFUD 37.5, PFU 16.7, PFUD 22.2. For the pharmacokinetic study. radiolaveled(-14C) drugs were used in liposome group and frozen vitreouses were measured by scintillatng counter; polymer group was measured by HPLC. The intravitreal half life(hour) of injected drugs were FU 3.2, FUMP 2.9, LFU 7.1, LFUMP 7.6, and PFU was exceptionally long(11.1 days).
