Expression of vascular endothelial growth factor and cyclooxygenase-2 in laryngeal squamous cell carcinoma and its significance.
- Author:
Guangli, CHEN
;
Yingpeng, LIU
;
Jianting, WANG
;
Linghui, LUO
;
Pei, CHEN
;
Juan, DING
;
Shusheng, GONG
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell/*metabolism;
Cyclooxygenase 2/*biosynthesis;
Cyclooxygenase 2/genetics;
Laryngeal Neoplasms/*metabolism;
RNA, Messenger/biosynthesis;
RNA, Messenger/genetics;
Tumor Markers, Biological;
Vascular Endothelial Growth Factor A/*biosynthesis;
Vascular Endothelial Growth Factor A/genetics
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2006;26(1):105-7
- CountryChina
- Language:English
-
Abstract:
In order to study the expressions of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) in human laryngeal squamous cell carcinoma (LSCC) and its significance, the expression of VEGF mRNA and COX-2 mRNA in 62 cases of LSCC and 54 adjacent noncancerous laryngeal tissues and 9 normal human laryngeal mucous tissues was detected by using techniques of semi-quantitative RT-PCR. It was found that the expression level of VEGF and COX-2 mRNA was significantly increased in LSCC as compared with that in the normal human laryngeal mucous tissues (both P < 0.01), and the expression level of VEGF and COX-2 mRNA were significantly increased in stage Ill + IV tissues of LSCC as compared with the stage I + II tissues of LSCC (P < 0.01). There was a high positive correlation between VEGF and COX-2 expression in LSCC (r = 0.756, P < 0.01). These data raise the possibility that VEGF and COX-2 may play key roles in the growth, invasion and metastasis of LSCC.
