Differences in Variation of Human Immunodeficiency Virus Type 1 Sequences from Henan and Shanghai Regions of China
- Author:
Chun-yu, YIN
;
Hong-zhou, LU
;
Wei-ming, JIANG
;
Maria Pia De PASQUALE
;
Yue-kai, HU
;
Xiao-zhang, PAN
;
Xin-hua, WENG
;
Richard T. D'AQUILA
;
Yi-Wei, TANG
- Publication Type:Journal Article
- Keywords:
HIV;
Transmission;
Phylogenetic analysis
- From:Virologica Sinica
2007;22(3):212-217
- CountryChina
- Language:Chinese
-
Abstract:
Illegally paid blood donation was a risk factor for HIV acquisition exclusively in Henan and Hubei Provinces of China, and not in Shanghai. Nucleotide sequences in the gag and env genes of HIV-1 were compared between isolates from Henan and Shanghai regions of China to test whether an expected higher degree of a common source of infections from this unique blood donation transmission risk would be evident as decreased variation among Henan isolates in an exploratory cross-sectional analysis. Among 38 isolates studied, 23 of 23 (100%) from Henan and 8 of 15 (54%) from Shanghai were subtype B. In addition, fewer sequence differences were found in gp41 of subtype B isolates from Henan than from Shanghai isolates. Further studies with additional controls are therefore warranted to confirm the role of the degree of a common source of infections in differences in HIV variation across populations.
