Current advance in gene therapy of retinoblastoma
10.3760/cma.j.issn.2095-0160.2011.01.024
- VernacularTitle:视网膜母细胞瘤基因治疗研究进展
- Author:
Juan, YAO
- Publication Type:Journal Article
- Keywords:
Retinoblastoma;
Gene therapy;
RNA interference
- From:
Chinese Journal of Experimental Ophthalmology
2011;29(1):92-96
- CountryChina
- Language:Chinese
-
Abstract:
Retinoblastoma (RB) is the most common infant eye malignant tumor.Conventional management mainly include enueleation of eyeball,evisceration of orbital tissue,radiotherapy and chemotherapy,but the prognosis is not significantly improved,and its long-term effects ale often devastating.Recent years,the development of gene therapy brings a chance for achieving the goal of treatment BB and improving patients'prognosis.The progress in gene therapy for RB,the vector of gene transfer,the methods of gene delivery and the commonly used technologies (RNA interference) to the therapeutic targets were reviewed.
