The lipid-regulating effects of atorvastatin on type 2 elder diabetes patients with hyperlipidemia.
- Author:
Ling, TU
;
Xiaoqing, LIU
;
Renli, LI
;
Kui, HUANG
;
Hanhua, YAO
;
Qiao, FAN
- Publication Type:Journal Article
- MeSH:
Anticholesteremic Agents/*therapeutic use;
Cholesterol, HDL/blood;
Cholesterol, LDL/blood;
Diabetes Mellitus, Type 2/*complications;
Diabetes Mellitus, Type 2/drug therapy;
Heptanoic Acids/*therapeutic use;
Hyperlipidemias/complications;
Hyperlipidemias/*drug therapy;
Pyrroles/*therapeutic use;
Triglycerides/blood
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2004;24(2):138-9
- CountryChina
- Language:English
-
Abstract:
To investigate the effect of atorvastatin on lipid metabolism in type 2 elder diabetes patients with hyperlipidemia, 26 patients with type 2 elder diabetes complicated with hyperlipidemia were treated with atorvastatin (10 mg/d) for 8 weeks. The serum triglyceride (TG), high density protein cholesterol (HDL-C) and low density protein cholesterol (LDL-C) were measured before and after the treatment. Meanwhile, the non-denaturing polyacrylamide gradient gel electrophoresis was used for detection of small-sized LDL(SLDL). Our results showed that TG dropped from 4.88 +/- 0.72 mmol/L to 2.65 +/- 0.32 mmol/L; HDL-C was increased from 0.85 +/- 0.31 mmol/L to 1.28 +/- 0.29 mmol/L; LDL-C was declined from 3.71 +/- 2.98 mmol/L to 2.10 +/- 1.22 mmol/L, sLDL-A was increased from (42.49 +/- 8.1)% to (53.27 +/- 7.5)%; LDL-B was decreased from (57.91 +/- 8.1)% to (46.73 +/- 7.5% ) (P<0.05). The level of blood glucose was not changed at the end of 8th week. It is concluded that atorvastatin has satisfactory lipid-regulating effects on type 2 elder diabetes patients with hyperlipidemia.
