Primary liposarcomas constitute less than 1% of all mediastinal tumors. The posterior mediastinum is the location in 95% of cases. Literature search did not show a case that encompassed three mediastinal compartments.
A 32-year old man was diagnosed with high grade primary mediastinal liposarcoma (80% myxoid plus 20% round cell), after presenting with superior vena cava syndrome. CT-scan revealed lobulated masses on the superior, anterior, and the right middle mediastinum measuring 7.8 x 9.0 x 7.5 cm and compressing the superior vena cava. He underwent surgical debulking and palliative 3 cycles doxorubicin-based chemotherapy, but later succumbed to pneumonia.