Authors suggest efforts are needed to further explore the usefulness and utilization of psychoeducation at the community and professional levels as applied to various settings and populations. In addition, if developed and implemented carefully, psychoeducational interventions have promising application on other life challenges across levels of the public health, social, and educational systems. This quasiexperimental three group pre-test post-test study aims to investigate the effect of psychoeducation on the self-esteem and self-efficacy of college students. A total of 105 college students (35 subjects per group) who were enrolled at Saint Louis University, Baguio City, Philippines were included as sample. Sampling technique was purposive. The Rosenberg's Self-esteem Scale and Schwarzer's General Selfefficacy Scale were used as data gathering tools. A self-made psychoeducational module that was validated by experts in mental health and psychiatric nursing was utilized as intervention. SPSS version 20 was used for the statistical analysis. The results on the post-test scores of both treatment arms (informational and comprehensive model) were significantly higher compared to control group after eight sessions of psychoeducation. The researchers therefore conclude that both psychoeducation models (informational and comprehensive) showed evidence of effectiveness in increasing the self-esteem and self-efficacy levels of college students.