Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis.
10.3349/ymj.2016.57.4.879
- Author:
Lei HE
1
;
Tao DENG
;
Hesheng LUO
Author Information
1. Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China. dengtao1120@hotmail.com
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
ALDH2;
polymorphism;
alcoholic liver cirrhosis;
meta-analysis
- MeSH:
Aldehyde Dehydrogenase, Mitochondrial/*genetics;
Asian Continental Ancestry Group/*genetics;
Case-Control Studies;
Genetic Predisposition to Disease;
Humans;
Liver Cirrhosis, Alcoholic/*ethnology/*genetics;
Odds Ratio;
Polymorphism, Genetic/*genetics;
Protective Factors
- From:Yonsei Medical Journal
2016;57(4):879-884
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations between the ALDH2 polymorphism and the risk of ALC. MATERIALS AND METHODS: Relevant studies were retrieved by searching PubMed, Web of Science, CNKI, Wanfang and Veipu databases up to January 10, 2015. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using either the fixed- or random effects model. RESULTS: A total of twelve case-control studies included 1003 cases and 2011 controls were included. Overall, the ALDH2 polymorphism was associated with a decreased risk of ALC (*1/*2 vs. *1/*1: OR=0.78, 95% CI: 0.61-0.99). However, in stratification analysis by country, we failed to detect any association among Chinese, Korean or Japanese populations. CONCLUSION: The pooled evidence suggests that ALDH2 polymorphism may be an important protective factor for ALC in East Asians.
