Cyclooxygenase-2 Inhibitor Reduces Hepatic Stiffness in Pediatric Chronic Liver Disease Patients Following Kasai Portoenterostomy.
10.3349/ymj.2016.57.4.893
- Author:
Hye Kyung CHANG
1
;
Eun Young CHANG
;
Seonae RYU
;
Seok Joo HAN
Author Information
1. Department of Pediatric Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Cyclooxygenase-2 inhibitors;
liver stiffness score;
hepatic fibrosis;
cholestatic liver disease;
biliary atresia
- MeSH:
Biliary Atresia/complications/enzymology/*surgery;
Child;
Child, Preschool;
Chronic Disease;
Cyclooxygenase 2 Inhibitors/*therapeutic use;
Female;
Humans;
Liver Cirrhosis/etiology/pathology/*prevention & control;
Male;
*Portoenterostomy, Hepatic;
Thiazines/*therapeutic use;
Thiazoles/*therapeutic use
- From:Yonsei Medical Journal
2016;57(4):893-899
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The purpose of this study was to define the role of cyclooxygenase-2 inhibitors (COX-2i) in reducing hepatic fibrosis in pediatric patients with chronic liver disease. MATERIALS AND METHODS: From September 2009 to September 2010, patients over 2 years old who visited our outpatient clinic for follow-up to manage their chronic liver disease after Kasai portoenterostomy for biliary atresia, were included in this study. Volunteers were assigned to the study or control groups, according to their preference. A COX-2i was given to only the study group after obtaining consent. The degree of hepatic fibrosis (liver stiffness score, LSS) was prospectively measured using FibroScan, and liver function was examined using serum analysis before and after treatment. After 1 year, changes in LSSs and liver function were compared between the two groups. RESULTS: Twenty-five patients (18 females and 7 males) were enrolled in the study group. The control group included 44 patients (26 females and 18 males). After 1 year, the least square mean values for the LSSs were significantly decreased by 3.91±0.98 kPa (p=0.004) only in the study group. Serum total bilirubin did not decrease significantly in either group. CONCLUSION: COX-2i treatment improved the LSS in patients with chronic liver disease after Kasai portoenterostomy for biliary atresia.
