Mobius sequence with prenatal exposure to misoprostol
- Author:
Marissa N. Valbuena
;
Alvina Pauline D. Santiago
;
Patricia Q. Grulla
- Publication Type:Case Reports
- MeSH:
Abducens Nerve Vestibulocochlear Nerve Paralysis
- From:
Philippine Journal of Ophthalmology
2009;34(1):28-33
- CountryPhilippines
- Language:English
-
Abstract:
Objective:To present 3 cases of Möbius sequence exposed in utero to misoprostol and discuss their clinical presentations, etiopathogenesis, and management.
Methods:Medical records of 3 patients with Möbius sequence and prenatal exposure to misoprostol were reviewed. Clinical findings were compared with those reported in the literature.
Results:Lack of facial-muscle movement, lagophthalmos with secondary exposure keratitis, decreased ability to crease forehead, and shallow nasolabial fold imply facial-nerve dysfunction. Small- and large-angle esotropia and apparent orthotropia with abduction limitation showed varying degrees of abducens nerve involvement. Two patients had early prenatal exposure to misoprostol during the first 3 months of gestation.
Conclusion:A history of misoprostol exposure should be routinely elicited from parents of children with Möbius sequence. Associated deficiencies in Möbius sequence and its variants require a multidisciplinary approach.
