Glutathione (GSH) is a naturally produced tripeptide composed of glutamine,glycine,and cysteine. GSH has several important metabolic and regulatory functions in our body but it is most popular for its antioxidant role. Oxidative stress states such as chronic diseases or low protein levels can deplete intracellular glutathione. Glutathione levels may be increased by correcting any protein deficiency, administering glutathione supplements or other precursors, usually by oral or intravenous routes. Glutathione supplements are generally considered safe to administer either intravenously or orally. Dermatologists need basic knowledge about glutathione supplements need to be scientifically studied by dermatologists before these supplements become part of our therapeutic options.