Concise Review: Differentiation of Human Adult Stem Cells Into Hepatocyte-like Cells In vitro.
10.15283/ijsc.2014.7.2.49
- Author:
Yunwei ZHANG
1
;
Lijuan XU
;
Shufang WANG
;
Changhao CAI
;
Li YAN
Author Information
1. Department of Gastroenterology, Institute of Geriatrics, China. yanlifmu@126.com
- Publication Type:In Vitro ; Review
- Keywords:
Adult stem cells;
Bone marrow-derived mesenchymal stem cells;
Adipose tissue-derived mesenchymal stem cells Peripheral blood monocytes;
Hepatocyte-like cells
- MeSH:
Adult;
Adult Stem Cells*;
Cell- and Tissue-Based Therapy;
Humans;
Mesenchymal Stromal Cells;
Monocytes;
Tissue Engineering
- From:International Journal of Stem Cells
2014;7(2):49-54
- CountryRepublic of Korea
- Language:English
-
Abstract:
Adult stem cells (ASCs) are undifferentiated cells found throughout the body that divide to replenish dying cells and regenerate damaged tissues, which are the powerful sources for cell therapy and tissue engineering. Bone marrow-derived mesenchymal stem cells (BMSCs), adipose tissue-derived mesenchymal stem cells (ADSCs), and peripheral blood monocytes (PBMCs) are the common ASCs, and many studies indicated that ASCs isolated from various adult tissues could be induced to hepatocyte-like cells in vitro. However, the isolation, culture protocols, characterization of ASCs and hepatocyte-like cells are different. This review aims to describe the isolation and culture procedures for ASCs, to summarize the molecular characterization of ASCs, to characterize function of hepatocyte-like cells, and to discuss the future role of ASCs in cell therapy and tissue engineering.
