Calciphylaxis is a rare condition primarily occurring in patients with end-stage renal disease and involving mural calcification of small vessels. It has a high mortality rate, with death in the majority of cases occurring from sepsis. Most cases are characterized by rapid progression of tender subcutaneous nodules or cutaneous plaques to epidermal necrosis. The condition is still poorly understood. This is a report of two cases, both females, 50 and 51 years of age, with chronic kidney disease undergoing hemodialysis and peritoneal dialysis respectively, three times a week. They presented with tender patches and plaques with subsequent development of eschars and ulceration. Biopsies confirmed the presence of calcification within vessel walls in the subcutis. They were both managed conservatively with proper wound care and surgical debridement but eventually expired after a few months.