Mistaken jewel: A case report on bullous pemphigoid in childhood.
- Author:
Sarao-Nazario Kathryn
;
Teodosio Gracia B.
- Publication Type:Case Reports
- Keywords: Childhood Bullous Pemphigoid; Direct Immunofluorescence; Indirect Immunofluorescence
- MeSH: Human; Female; Infant; Autoantigens; Basement Membrane; Blister; Cicatrix; Histamine H1 Antagonists; Immunoglobulin A; Immunoglobulin G; Linear Iga Bullous Dermatosis; Pemphigoid, Bullous; Pruritus
- From: Journal of the Philippine Dermatological Society 2013;22(2):50-54
- CountryPhilippines
- Language:English
-
Abstract:
Bullous pemphigoid (BP) is an acquired sub-epidermal immune-mediated blistering disease associated with a humoral and cellular response directed against self-antigens. Childhood BP is uncommon with only <80 reported cases in literature.Often, lesions of childhood BP are localized rather than widespread; and, acral distribution is more common among infants. Clinically, it is often confused with chronic bullous disease of childhood (CBDC). BP can be differentiated from CBDC by the presence of immunoglobulin (Ig) G antibodies, rather than IgA at the basement membrane zone on direct immunofluorescence (DIF). We present a case of childhood BP in a one-year-old baby girl who presented with CBDC-like lesions. DIF showed IgG and C3 at the basement membrane zone. Treatment given included topical and oral sterioids due to the extent of lesions as well as antihistamine to reduce pruritus. Most of the lesions improved after two weeks and 80% resolved after two month of treatment with no note of scarring. However, continuous monitoring of the patient is advised due to the need for long-term treatment of these patients.