Twenty-four-hour radioactive iodine uptake (RAIU) is commonly used to compute for therapy dose in Graves disease (GD). The purpose of this study is to determine the feasibility of using 4-hour RAIU in calculating the dose by correlating 4-hour with 24-hour RAIU and comparing the actual therapy dose using 24-hour RAIU with the computed dose using 4-hour RAIU. A total of 83 GD patients (71% female, 29% male;18-50 years old), who underwent RAI therapy at USTH Section of Nuclear Medicine, were included. There was a strong and positive correlation between 4-hour and 24-hour RAIU values (r=0.736). Paired t-test did not show a statistical difference between the actual given therapy dose based on 24-hour RAIU and the computed therapy dose using 4-hour RAIU (p 0.078). This study showed that therapy dose calculation using 4-hour RAIU can be used in Graves disease patients with no rapid turnover.