- Author:
Jyotsna Oak
1
;
Girish Parmar
1
;
Satish Sharma
1
;
Bijal Kulkarni
1
;
Laxmi Patil
1
Author Information
- Publication Type:Case Reports
- Keywords: X-linked Hypophosphatemic Rickets; Autosomal Dominant Hypophosphatemic Rickets; Fibrous Dysplasia; Tio; Fgf23
- MeSH: Human; Female; Middle Aged; Adenoma, Pleomorphic; Connective Tissue; Hypophosphatemia; Hypophosphatemia, Familial; Lower Extremity; Neoplasms, Connective Tissue; Paraneoplastic Syndromes; Parotid Gland; Parotid Neoplasms; Vitamin D; Hypophosphatemia
- From: Journal of the ASEAN Federation of Endocrine Societies 2016;31(2):171-177
- CountryPhilippines
- Language:English
-
Abstract:
Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome, which is characterized by overproduction of FGF23 as a phosphaturic agent leading to chronic phosphaturia and hypophosphatemia, associated with inappropriately normal or low levels of vitamin D. We describe a rare case of a 57-year-old Indian female who presented with bone pains, muscle pains and lower limb weakness. On examination she was found to have hypophosphatemia. Our work up led to the identification of a FGF23 secreting parotid tumour. The tumour responsible for symptoms was a pleomorphic adenoma of the parotid gland. Its complete resection resulted in normalisation of patient's symptoms. Laboratory parameters and microsopic examination further revealed a mesenchymal tumour of mixed connective tissue type.
- Full text:330-Article Text-4094-1-10-20161128.pdf