A comparison of sodium bicarbonate and sodium hyaluronidase as adjuncts in peribulbar blockade
- Author:
Estaquio CM
;
Guballa HP
;
Reyes AL
- Publication Type:Case Reports
- MeSH:
Human;
Aged;
Middle Aged;
CATARACT SURGERY;
CATARACT EXTRACTION;
SODIUM BICARBONATE;
BICARBONATES AND SODIUM;
- From:
Philippine Journal of Ophthalmology
2003;28(1):13-29
- CountryPhilippines
- Language:English
-
Abstract:
Study Design: prospective, randomized, double-blinded clinical trial; Objective: To compare the efficacy of peribulbar block augmentated with sodium bicarbonate to that augmented with sodium hyaluronate; Subjects: 99 eyes from 94 patients undergoing cataract surgery divided into 3 groups receiving either anesthetic alone, anesthetic with bicarbonate, or anesthetic with hyaluronidase; Observation Parameters: (1) lid and ocular sensitivity to pain immediately after anesthetic injection, 30 minutes after injection and immediately after surgery, (2) onset and duration of lid and ocular analgesia and akinesia, (3) complications, and (4) the need for supplemental injections; Data Analysis: Mean onset of analgesia and akinesia, pain scores and motion scores were determined. F-test ANOVA followed by post-hoc tests (- LSD and Duncans Multiple Range Test) were used to analyze continuous data. Kruskall-Wallis test ANOVA followed by pair-wise comparison using Mann-Whitney U tests were used to analyze ordinal data. Chi square was used to analyze nominal data. Wilcoxon Signed Ranks test was used for within group analysis after data splitting. Relative risk, relative risk reduction, absolute risk reduction, and number needed to treat, were also computed. Conclusion: Peribulbar blockade using sodium bicarbonate as adjunct was found to be as effective as that which was augmented with hyaluronidase. Anesthetic solutions with additives (sodium bicarbonate or hyaluronidase) were found to be superior to pure anesthetics in terms of latency, intensity of analgesia, and degree of akinesia.
