Risk factors associated with malignant endometrial lesions in postmenopausal women presenting with abnormal uterine bleeding: a retrospective review
- Author:
Uy Irene L.
;
Fernandez Ma.Asuncion
;
Bautista-Zamora Brenda Bernadette P.
- Publication Type:Journal Article
- MeSH:
Human;
Female;
Aged;
Middle Aged;
ENDOMETRIAL NEOPLASMS;
HYSTEROSCOPY;
MENORRHAGIA;
UTERINE HEMORRHAGE
- From:
Philippine Journal of Reproductive Endocrinology and Infertility
2010;7():1-6
- CountryPhilippines
- Language:English
-
Abstract:
Objectives: To identify clinical, sonographic and hysteroscopic characteristics associated with malignant endometrial lesions.
Methods: This is a retrospective descriptive study that included all menopausal women presenting with vaginal bleeding in a tertiary care hospital from January 2007 to June 2010. Clinical, sonographic and hysteroscopic findings were evaluated as predictor variables for development of endometrial adenocarcinoma.
Results: Thirteen out of the 215 patients had endometrioid adenocarcinoma, in women presenting with postmenopausal bleeding, with a prevalence rate of 6%. A trend towards harm is seen among the following factors: age of > 60 years (OR 1.19; 95% CI, 0.29-4.46), menarche < 12 years (OR 1.07; 95% CI, 0.22-4.66), endometrial stripe >/- 10mm (OR 2.02; 95% CI, 0.58-7.09), lesion of diameter < 1cm (OR 1.57; 95% CI, 0.45-5.74), presence of cystic space (OR 4.28; 95% CI, 1.00-17.36), and soft consistency (OR 1.94; 95% CI, 0.47-9.21).
Conclusion: Increasing age, early onset of menarche, endometrial thickness of >/- 10mm, hysteroscopic characteristics (lesion diameter of less than 1 em, presence of cystic space and soft consistency) increases the probability of carcinoma.
