The correlation between time of administration of clomiphene citrate and its anti-estrogenic effects of endometrial thickness and endometrial pattern: randomized single-blinded trial
- Author:
Mendiola Rudie Frederick B.
;
De Guia Blanca C.
- Publication Type:Journal Article
- MeSH:
Human;
Female;
CLOMIPHENE
- From:
Philippine Journal of Reproductive Endocrinology and Infertility
2005;2(1):9-12
- CountryPhilippines
- Language:English
-
Abstract:
It remains controversial whether the day of initiation of clomiphene citrate (cc) has any impact on endometrial quality.
Objective:To determine the correlation between time of administration of clomiphene citrate and its anti-estrogenic effects on endometrial thickness and endometrial pattern.
Methods: Filipino women consulting at the Philippine General Hospital for difficulty in conceiving were randomized into two groups either to start CC on cycle day two or day five. Transvaginal ultrasonography was used to determine differences in endometrial thickness and endometrial pattern between the two groups. Students t-test and chi square were used for data analysis.
Results: There was no difference in endometrial thickness between the two groups. There were significantly more subjects with trilaminar endometrium in the day two groups.
Conclusion: Mean endometrial thickness was similar in both arms. Earlier administration, starting day two favors the development of trilaminar endometrium.
