Relationship between estrogen receptor thymine-adenine repeat polymorphism and effects of hormone replacement therapy on serum lipid and bone density in postmenopausal women.
- Author:
Chang Hoon YIM
1
;
Chang Sun HWANG
;
Young Soon KANG
;
In Kul MOON
;
Sung Hoon KIM
;
Ho Yeon CHUNG
;
Ki Ok HAN
;
Hak Chul JANG
;
Won Keun PARK
;
Hyun Ku YOON
;
In Kwon HAN
;
Yong Soo PARK
;
Dong Sun KIM
;
You Hern AHN
;
Tae Hwa KIM
Author Information
1. Department of Interanl Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Estrogen receptors;
Polymorphism;
Hormone replacement therapy;
Lipids;
Bone density
- MeSH:
Bone Density*;
Cholesterol;
Cholesterol, HDL;
Cholesterol, LDL;
Estrogen Receptor alpha;
Estrogens*;
Female;
Hormone Replacement Therapy*;
Humans;
Metabolism;
Receptors, Estrogen;
Triglycerides
- From:Korean Journal of Medicine
2003;65(2):205-214
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Several biologically plausible mechanisms have been proposed for estrogen-associated changes in lipid and bone metabolism. These effects are thought to be mediated via estrogen receptor (ER). Several polymorphisms in the gene encoding estrogen receptor alpha may modify the effects of hormone replacement therapy on lipid and bone density in postmenopausal women. METHODS: We examined 284 postmenopausal women for thymine-adenine (TA) repeat polymorphism at the ER gene locus and its relationship to lipid and bone density. Their mean age was 52.2+/-5.0 years. We also investigated the association between ER TA repeat polymorphism and changes in lipid and bone density after 3 months and 1 year of hormone replacement therapy. RESULTS: According to the mean number of TA repeats, the women were divided into two groups: group H, with higher number of repeats (TA>16)(n=110); group L, with lower number of repeats (TA
