A comparative study using lidocaine, thiopental and metoclopramide as pre-treatment in reducing propofol pain on injection
- Author:
Florendo Joanna V.
;
Barrios Theresa
;
Laborte Nelia
;
Reyes Jocelyn
- Publication Type:Journal Article
- MeSH:
Human;
LIDOCAINE;
THIOPENTAL;
METOCLOPRAMIDE;
PROPOFOL;
PAIN MANAGEMENT;
ANESTHESIA
- From:
Philippine Journal of Anesthesiology
2008;20(2):25-31
- CountryPhilippines
- Language:English
-
Abstract:
Methods: In a randomized, double-blinded, placebo-controlled trial, 144 ASA I-II patients, scheduled for elective surgery under general anesthesia were randomly assigned to 1 of 4 groups. Group I received 2 ml of plain NSS, group II received lidocaine 40 mg, group III received thiopental 0.5mg/kg and group IV received metoclopramide 10 mg. All pretreatment drugs were made into 2 ml solutions and were given IV with manual venous occlusion of 1 minute. Propofol was administered after release of venous occlusion. pain was then assessed using a four-point scale and face pain scale during propofol injection.
Results: 36 patients (100%) complained of pain in the control group compared with 20 (56%), 22 (61%) and 23 (64%) in the lidocaine, thiopental and metoclopramide groups, respectively (p<0.05). there was no significant difference among the 3 test solution with regards to severity of pain. Nor were there any noted complications 24 hours postoperatively on the injection site.
Conclusion: Thiopental and metoclopramide are equally effective as lidocaine in reducing pain during propofol injection when used with manual venous occlusion.
