A case of minimal change nephrotic syndrome associated with systemic lupus erythematosus.
- Author:
Hee Rin JOO
1
;
Won Suk AN
;
Sung Won LEE
;
Won Tae JUNG
;
Seo Hee RHA
;
Seong Eun KIM
;
Ki Hyun KIM
Author Information
1. Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. sekim@mail.donga.ac.kr
- Publication Type:Case Report
- Keywords:
Minimal Change Nephrotic Syndrome;
Systemic Lupus Erythematosus;
T-cell Dysfunction
- MeSH:
Adult;
Antigen-Antibody Complex;
Autoimmune Diseases;
Biopsy;
Female;
Glomerulonephritis, Membranous;
Humans;
Lupus Erythematosus, Systemic*;
Nephrosis, Lipoid*;
Nephrotic Syndrome;
Prednisolone;
Proteinuria;
T-Lymphocytes
- From:Korean Journal of Medicine
2003;65(2):251-255
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the overprocuctionofautoantibodiesandthedepositionofimmune complexes in various organs. Unusual case of systemic lupus erythematosus (SLE) associated with minimal change nephrotic syndrome(MCNS) is described. A 30-year-old woman who has been diagnosed as SLE and treated with prednisolone presented symptoms of nephrotic syndrome. Renal biopsy revealed minor glomerular abnormalities without deposition of immune complexes. The initial heavy proteinuria promptly decreased after the prednisolone dosage was increased and disappeared 10 weeks later. She developed proteinuria again 3 years after the initial episode. Repeated renal biopsy revealed membranous nephropathy. T-cell dysfunction, which is present both in SLE and MCNS, might have triggered MCNS during the course of SLE.
