Effects of conjugated equine estrogen on endometrium of patients taking clomiphene citrate
- Author:
Villamayor Teresa Q.
;
Flores-Medina Mary Joyce
;
Ochoco-Sotto Ma. Regale N.R.
;
Mayuga-Anes Maria Cecilia
;
De Guia Blanca C.
- Publication Type:Journal Article
- MeSH:
Human;
Female;
Adult;
ESTROGENS, CONJUGATED (USP);
CLOMIPHENE;
ENDOMETRIUM
- From:
Philippine Journal of Reproductive Endocrinology and Infertility
2004;1(1):12-15
- CountryPhilippines
- Language:English
-
Abstract:
Objectives: To compare the effects of clomiphene citrate with conjugated equine estrogen (early or beginning day 2 of menses vs. late or beginning day 7 of menses) and clomiphene citrate alone on endometrial thickness and pattern (i.e. trilaminar or non-trilaminar) among patients for induction of ovulation.
Study Design: Prospective, randomized
Setting: tertiary care hospital
Inclusion criteria: Women aged 25-40 years old with infertility of at least 2 years duration who are candidates for ovulation induction.
Exclusion criteria: Women on hormonal treatment 1 month prior to ovulation, with ovarian cysts, mullerian abnormalities, myomas or uterine cavity abnormalities.
Results: Fifty-four women were included in the study with mean age 31.093 years +/- 4.655 (range 21 to 40 years), duration of infertility 4.954 +/- 3.228 (range 2 to 20 years), and day of the cycle when dominant follicle was noted was 11.907 +/- 1.751 (range of 8 to 16 days). Mean endometrial thickness was 0.960 cm in group I, 1.053 cm in group II and 0.850 cm in group III with a p value of 0.040625. There was significant improvement in thickness from baseline with a p value of 0.015166. There was no significant effect on endometrial pattern (p value = 0.236146).
Conclusion: The addition of conjugated equine estrogens in ovulation induction with clomiphene citrate improves endometrial thickness.
