A Case of Acute Kidney Injury in a Patient with Pulmonary Tuberculosis Receiving Ethambutol Therapy.
10.3904/kjm.2014.87.3.352
- Author:
Chang Woo HONG
1
;
Sin Young NHO
;
In Hee LEE
;
Ki Sung AHN
;
Kwan Kyu PARK
;
Gun Woo KANG
Author Information
1. Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. gwkang4540@hanmail.net
- Publication Type:Case Report
- Keywords:
Ethambutol;
Interstitial nephritis;
Acute kidney injury
- MeSH:
Acute Kidney Injury*;
Aged;
Biopsy;
Blood Urea Nitrogen;
Creatinine;
Edema;
Ethambutol*;
Humans;
Nausea;
Nephritis, Interstitial;
Optic Nerve Diseases;
Tuberculosis;
Tuberculosis, Pulmonary*;
Vomiting
- From:Korean Journal of Medicine
2014;87(3):352-356
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Ethambutol is commonly used as a first-line drug for the treatment of tuberculosis. The most serious adverse effect of ethambutol therapy is optic neuropathy. However, ethambutol-induced acute kidney injury is extremely rare. We report herein a case of acute kidney injury secondary to ethambutol-associated acute interstitial nephritis. A 65-year-old man with pulmonary tuberculosis presented with a > 7-day history of nausea and vomiting. He had begun antituberculosis medications including ethambutol 3 weeks previously. His laboratory findings showed elevated blood urea nitrogen and serum creatinine levels (32.6 and 3.6 mg/dL, respectively). Examination of percutaneous renal biopsy specimens showed diffuse interstitial mononuclear cell infiltration with mild interstitial edema. The patient was treated by cessation of ethambutol and supportive care. His renal function completely recovered (creatinine, 1.1 mg/dL) and his clinical symptoms improved.
