Chromosomal structural abnormalities among Filipino couples with recurrent pregnancy losses
- Author:
Cutiongco-Dela Paz Eva Maria
;
Dion-Berboso April Grace
;
Salonga Edsel Allan G.
;
David-Padilla Carmencita
- Publication Type:Journal Article
- MeSH:
Male;
Female;
RECURRENCE;
PREGNANCY;
CHROMOSOME ABERRATIONS;
ABORTION, SPONTANEOUS;
FEMALE UROGENITAL DISEASES AND PREGNANCY COMPLICATIONS;
PREGNANCY COMPLICATIONS;
- From:
Acta Medica Philippina
2011;45(4):58-62
- CountryPhilippines
- Language:English
-
Abstract:
Introduction. Recurrent pregnancy loss is a devastating reproductive problem that affects 5% of couples trying to conceive. Majority of the cases are due to cytogenetic errors. This study determines the prevalence of chromosomal structural abnormalities in Filipino couples who presented with 2 or more pregnancy losses.
Methods. Results from chromosomal analysis of couples referred for 2 or more miscarriages done at the Institute of Human Genetics-National Institutes of Health-University of the Philippines, Manila on peripheral blood samples from 1991 to 2010 were restrospectively reviewed.
Results. There were 356 couples with a history of 2 or more miscarriages sent for chromosomal analysis from 1991-2010 included in this study. Among these 356 couples, 17 couples (4.8%) were found to be carriers of different chromosomal abnormalies. From a total of 18 cases, there were 13(3.6%) translocations, 1(0.3%) insertion, 2(0.6%) with marker chromosomes, 1(0.3%) pericentric inversion and 1(0.3%) deletion.
Conclusion. The overall frequency of chromosomal structural abnormalities among patients with RPL in this study is 4.8% with translocations being the most common type detected. The results of this study are similar to that of previous large-scale studies which have demostrated that parental chromosomal abnormalities are associated with RPL.
