Study on the role of Aryl-hydrocarbone - receptor (AhR) in the induction CYP1A1 by serum
- Author:
Nguyen Quoc Binh
- Publication Type:Journal Article
- Keywords:
serum, Aryl-hydrocarbone, receptor, CYP1A1
- MeSH:
Cytochrome P-450 Enzyme System;
Serum;
Enzymes
- From:Pharmaceutical Journal
2005;0(5):16-19
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Cytochroms P450 (CYPs) are hemoprotein enzyme which play an important role in transformation endogenous and exogenous compounds. Among them, CYPs, isoform CYP1A1 have effection in biological activation many procarcinogens. The study is in order to research aryl hydrocarbon receptor (AhR) role in CYP1A1 induction by serum. Raw materials: Using human cell lines CaCo-2, HT 29-D4 and two colon of rat liver cell line Hepa 1c1c7. CaCo-2 and HT 29-D4 were taken from CNRS 6032-Marseille-France center, clons of Hepa supplied by Dr Hankinson. Result: Ah receptor is necessary for CYP1A1 induction by serum but not suffucient and the reason bring about induction is not due to serum infected agonist of AhR
