Serum total testosterone, follicle stimulating hormone and luteinizing hormone in aging males
- VernacularTitle:Эрэгтэйчүүдийн насжилтын үеийн нийт тестостерон, фолликул идэвхижүүлэгч даавар болон лютеинжүүлэгч даавруудыг судалсан дүн
- Author:
Munhtsetseg Sh
;
Munhtsetseg J
- Publication Type:Journal Article
- Keywords:
aging males;
total testosterone;
follicle stimulating hormone;
luteinizing hormone
- From:Mongolian Medical Sciences
2011;172(2):33-35
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background: Most of the country has been increasing the life expectancy and to relate aging man also have been increasing among population. Affected by human aging internal major factor is the change of Hypothalamus-Pituitary-Gonadal axis. Thus, we have proposed to study to change of regulating gonadothropin-gonadal axe in aging males.
Goal: To study the serum total testosterone, gonadothropin hormones level in aging males and its correlation with aging.
Materials and Methods: In this study were involved 149 healthy Mongolian men aged above 35 years. Subjects were randomly selected. Blood samples were collected in the morning 8.30-10.00 AM, 4ml blood from vein vassal. The serum concentration of total testosterone, luteinizing hormone, follicle stimulating hormone was assayed by ELISA.
Results: Total participant’s average age was 57.8±13.4 years. Average level of testosterone was 4.95±2.08ng/ml and there is no significant correlation with aging (r=0.084, p=0.331). But average level of FSH was 9.12±9.09 IU/L and FSH has increased with aging. Between age and FSH was found moderate and direct correlation (r=0.425, p<0.001). Average level of luteinizing hormone was 11.41±9.83 IU/L and LH had significant, direct correlation with
age (r=0.216, p<0.05). Gonadothropins FSH and LH were analyzed by ANOVA in different age groups and have not identified significant difference between age groups. Which allows hypothesize that in gonadotropins secretion no
rapid change in age different groups.
Conclusions:
1. Average level of testosterone in participating men was 4.95±2.08ng/ml and there is no significant correlation with aging (r=0.084, p=0.331).
2. Average level of FSH was 9.12±9.09 IU/l, had age related significant correlation (r=0.425, p<0.001), average level of LH was 11.41±9.83 IU/l and had significant, direct correlation with age (r=0.216,
p<0.05). Not found significant difference between age groups. 3. Multiple regression analyze showed insignificant (p>0.05) correlation of LH (β=0.170) with Testosterone, which was stronger than FSH (β=0.156).
- Full text:P020170215507202736900.pdf
